
Best to stay stealthy and avoid combat whenever possible. It’s also good preparation for permadeath.

While you can do it on the next run it would certainly make things easier if you don’t have to deal with it in permadeath mode.

Do all the side missions as they pop up on your mission list.By backing up your save and making a save game in every mission you can quickly go back and mop things up you may have missed. This is where you have to make story decisions that will change the outcome of the game. Create a backup of your saves on a USB device or PS+ Cloud after mission 10. You are advised to create a manual save at the start of every mission. The only things you should have left after this are “Pacifist”, “Foxiest of the Hounds”, “I Never Asked for This” and some story decision-based trophies. On the first playthrough you should thoroughly explore and get pretty much all trophies out of the way. Play Bank Heist Story Path after Mission 10. Get all eBooks, do all Side Missions, get miscellaneous and combat trophies. Minimum Playthroughs: 2+ (1 x all miscellaneous trophies, collectibles & first ending, 1 x highest difficulty with stealth and no kills). NG+ may be required for some of the upgrade related trophies, depending on how well you allocated your upgrade points.It’s unlocked after beating the game on any difficulty for the first time.

Does difficulty affect trophies?: Yes, you have to beat it on “I Never Asked For This” (highest difficulty).Most side quests will fail when going past mission 13, the point of no return)

Some trophies require certain story decisions.
